The Federal Ministry of Innovation, Science and Technology is a Nigerian ministry whose mission is to facilitate the development and deployment of science and technology apparatus to enhance the pace of socio-economic development of the country through appropriate technological inputs into productive activities in the nation. It is headed by a Minister appointed by the President, assisted by a Permanent Secretary, who is a career civil servant. President Bola Tinubu, GCFR on 16 August 2023 appointed Uche Nnaji as the Minister of Science and Technology. Mr James Sule, mni is the current permanent secretary in the ministry.

The Ministry was renamed to Federal Ministry of Innovation, Science and Technology on 6 August 2021.